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While medications are intended to make you feel better, they can sometimes have unwanted side effects. Ototoxicity refers to inner ear damage from exposure to certain drugs or chemicals, leading to hearing loss, tinnitus, and balance issues. 

In this article, we’ll look at what causes ototoxicity, the symptoms, and how awareness can help in prevention and early intervention.  

Causes of Ototoxicity

Ototoxicity happens when certain substances adversely affect the inner ear's cells that are responsible for hearing and balance. Common causes include: 

Medications

Certain over-the-counter and prescription drugs have ototoxic properties. We’ll provide a brief ototoxic drugs list later in this article. 

Chemicals

Exposure to heavy metals (lead, mercury), solvents (toluene) and asphyxiants (carbon monoxide, tobacco smoke) can be ototoxic.  Touching or breathing in chemicals or eating or drinking contaminated substances can lead to exposure. 

Environmental Factors

Being around loud noises while simultaneously experiencing ototoxic exposure can make ear damage even worse. 

Ototoxicity Symptoms

You may notice signs and symptoms right away as you start taking new medications, or it may develop over time. These symptoms often include:

Tinnitus

 This is usually the first symptom reported. Tinnitus can include hearing sounds others don’t hear, such as ringing, clicking, static, buzzing, or hissing sounds. 

Hearing Loss

Ototoxic hearing loss could manifest in one or both ears. It could look like not being able to understand what’s being said or needing higher volumes on your TV. 

Balance Issues

This could include dizziness, unsteady gait, or vertigo

Feeling of Fullness in the Ears

This is sometimes also described as feeling pressure in the ears. 

If you notice these symptoms and think they’re connected to your medications or exposure to chemicals, talk to your doctor right away. Early symptom recognition can help prevent further damage. 

Common Ototoxic Drugs

Over 200 medications are known to be ototoxic. Let’s look at a few ototoxic medication types: 

Aminoglycoside Antibiotics

These medications are often used for severe, life-threatening bacterial infections. Ototoxic antibiotics may include:

  • Amikacin
  • Gentamicin
  • Neomycin
  • Streptomycin
  • Tobramycin
  • Vancomycin

Chemotherapy Agents

Platinum-based drugs for cancer treatment. Examples:

  • Carboplatin
  • Cisplatin

Loop Diuretics

Treat serious fluid retention and hypertension.

Examples:

  • Bumetanide (Bumex)
  • Ethacrynic Acid (Edecrin)
  • Furosemide (Lasix)
  • Torsemide

Salicylates

High doses (6-8 gm/ day) can be ototoxic. 

Example:

  • Aspirin


Quinine

Used for malaria treatment and found in over-the-counter leg cramp remedies.

Antibiotics

Ototoxic antibiotics can include:

  • Erythromycin
  • Azithromycin
  • Clarithromycin

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Examples:

  • Ibuprofen
  • Naproxen 

Before you start taking new medication, talk to your healthcare providers about potential ototoxic effects.

Is Ototoxicity Reversible?

Ototoxicity can sometimes be reversible, but it depends on the specific drug, dosage, how long exposure has been going on, and overall health. In many cases, stopping the medication can lead to partial or full recovery of hearing or balance function. 

However, ototoxicity may cause permanent damage, especially if exposure is prolonged or the inner ear is particularly sensitive. To minimize the risk of long-term effects, you’ll want to have regular hearing assessments during treatment with known ototoxic drugs.

Ototoxicity Treatment: What Can Be Done

While there's no universal cure, there are steps you can take. If your doctor allows, stop or reduce exposure to the ototoxic substance or look at switching to another medication. If hearing loss is significant and permanent, your healthcare provider may recommend talking to an audiologist about hearing aids. 

Preventing and Managing Ototoxicity

Steer Clear

If possible, avoid working with ototoxic chemicals. If that’s not an option, always wear protective gear, including gloves and a mask, and follow recommended safety protocols. 

Review Your Medications

Discuss potential side effects with your doctor. If you have questions, don’t be afraid to ask them! If possible, talk to your healthcare provider about potential non-ototoxic medication options. 

Monitor Your Hearing Health

If you’re currently taking ototoxic medications, make sure to schedule routine hearing and balance assessments. Tell your healthcare provider immediately if you notice new symptoms, even if you’ve been on the medication for a while. 

Address Hearing Loss

If you have ototoxicity-induced hearing loss, hearing aids can improve your daily life, allowing you to connect to the sounds around you. 

Amplifon is Here to Help

Amplifon Hearing Health Care offers comprehensive support for individuals with a range of hearing health conditions. Services include access to a wide range of hearing aids so you can find the right fit. Make informed decisions about your hearing health with education on hearing loss prevention and management

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Do You Have Hearing Loss?

Too often, people wait to get an official hearing loss diagnosis. But addressing hearing loss can drastically improve your quality of life. Make an appointment with an audiologist, and let’s find out what’s going on.

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